Article
High-fat diet modifies the PPAR-γ pathway leading to disruption of microbial and physiological ecosystem in murine small intestine.
Proceedings of the National Academy of Sciences of the United States of America - 4 Oct 2016
Tomas Julie, Mulet Céline, Saffarian Azadeh, Cavin Jean-Baptiste, Ducroc Robert, Regnault Béatrice, Kun Tan Chek, Duszka Kalina, Burcelin Rémy, Wahli Walter, Sansonetti Philippe J, Pédron Thierry
Abstract excerpt
Diet is among the most important factors contributing to intestinal homeostasis, and basic functions performed by the small intestine need to be tightly preserved to maintain health. Little is known about the direct impact of high-fat (HF) diet on small-intestinal mucosal defenses and spatial distribution of the microbiota during the early phase of its administration. We observed that only 30 d after HF diet...
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