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Genetic Risk for Depression Associates with Circulating Immunoregulatory Natural Killer Cells Independent of BMI: An Exploratory Immunophenotyping Study.

Cells - 29 Jun 2026

Fyka Aikaterini, Anastasopoulou Dimitra, Livadara Marina, Eliopoulos Aristides G, Gkouskou Kalliopi

Abstract excerpt

Depressive disorders and obesity are highly comorbid conditions sharing genetic, metabolic, and immunological substrates. In a cross-sectional analysis of 53 participants across the obesity spectrum (lean n = 12; overweight n = 9; obese n = 32), a depression genetic risk score (d-GRS) correlated positively with BMI (ρ = 0.379, p = 0.005) and with serum CRP (ρ = 0.322, p = 0.031), consistent with the known genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42439656
DOI: 10.3390/cells15131179
PMCID: PMC13359601

Genes

CRP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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