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Article

CD8+ T Cells in Acute Lymphoblastic Leukemia Show a Progenitor-exhausted Phenotype.

Iranian journal of allergy, asthma, and immunology - 3 Jun 2026

Akbar Armin, Asgarian-Omran Hossein, Valadan Reza, Najafi Ahmad, Shekarriz Ramin, Zaboli Ehsan, Eslami-Jouybari Mohammad, Karami Hossein, Naderisoraki Mohammad, Tehrani Mohsen

Abstract excerpt

Exhausted T cells are phenotypically and functionally heterogeneous, from progenitor- to terminally-exhausted T cells. We evaluated gene expression profile of CD8+ T cells in acute leukemia to characterize the phenotype of exhausted T cells. Blood samples were collected from acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) patients prior to treatment and from control subjects. Additionally,...

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Identifiers

PMID: 42437313

Genes

BATF
TCF7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 12 Sept 2026.

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