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Article

Generation of Patient-Derived Colorectal Cancer Organoids for RAS Studies.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021

Schumacher Dirk, Regan Joseph L, Przybilla Dorothea, Schäfer Reinhold

Abstract excerpt

Human cell line models have been widely used for testing of novel anticancer compounds and for predicting clinical response to monotherapies and combinatorial therapies. For many years, standard monolayer culture conditions were used as gold standard, only surpassed by in vivo testing of mouse models. Recently, the incorporation of three-dimensional culture has been shown to further improve predictive compound...

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PMID: 33977489
DOI: 10.1007/978-1-0716-1190-6_22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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