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Article

DDAH1 and DDAH2 drive vasculogenic mimicry and more aggressive phenotypes in triple negative breast cancer cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Aug 2026

Meyers Jai, Weerakoon Lashika, Ragavan Vinitha, Jarzebska Natalia, Rodionov Roman N, Mangoni Arduino A, Hulin Julie-Ann, Tommasi Sara

Abstract excerpt

The overexpression of dimethylarginine dimethylaminohydrolase 1 (DDAH1) and 2 (DDAH2) has been associated with several types of cancer. Specifically, DDAH1 has been shown to play a critical role in the establishment of a vascular network by tumour cells, vasculogenic mimicry (VM), in triple negative breast cancer (TNBC). In turn, VM favours TNBC progression and is associated with poor patient prognosis. DDAH1 is...

Topics

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Amidohydrolases
Arginine
Cell Movement
Cell Proliferation
Neoplasm Invasiveness

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neovascularization, Pathologic

Triple Negative Breast Neoplasms

Vascular Endothelial Growth Factor A

Source

Identifiers

PMID: 42430838
DOI: 10.1016/j.biopha.2026.119759

Genes

DDAH2
DDAH1
MB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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