Article
Improving lung cancer risk stratification leveraging whole transcriptome RNA sequencing and machine learning across multiple cohorts.
BMC medical genomics - 22 Oct 2020
Choi Yoonha, Qu Jianghan, Wu Shuyang, Hao Yangyang, Zhang Jiarui, Ning Jianchang, Yang Xinwu, Lofaro Lori, Pankratz Daniel G, Babiarz Joshua, Walsh P Sean, Billatos Ehab, Lenburg Marc E, Kennedy Giulia C, McAuliffe Jon, Huang Jing
Abstract excerpt
BACKGROUND: Bronchoscopy for suspected lung cancer has low diagnostic sensitivity, rendering many inconclusive results. The Bronchial Genomic Classifier (BGC) was developed to help with patient management by identifying those with low risk of lung cancer when bronchoscopy is inconclusive. The BGC was trained and validated on patients in the Airway Epithelial Gene Expression in the Diagnosis of Lung Cancer (AEGIS)...
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