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Article

Establishment and characterization of TRI-LC21: a novel patient-derived cell line of SMARCA4-deficient undifferentiated thoracic tumor.

Human cell - 9 Jul 2026

Li Shasha, Luo Hao, Wu Dongsheng, Ku Yin, Luo Nanzhi, Gong Zhipeng, Zhou Wenjing, Xie Xinyi, Zhou Guanyu, Chen Yaohui, Liu Lunxu

Abstract excerpt

SMARCA4-deficient thoracic undifferentiated tumor is a rare and highly aggressive subtype of lung cancer defined in the 2021 World Health Organization classification. Its scarcity and highly undifferentiated histology limit the availability of representative in vitro models and hinder therapeutic development. In this study, we established a novel cell line, TRI-LC21, from the primary tumor of a patient with lung...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42426436
DOI: 10.1007/s13577-026-01418-9
PMCID: PMC13350128

Genes

SMARCA4
ARHGAP35
RBM10
STK11
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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