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Article

Aberrant TMPRSS6-Protease Regulation of Disease Mutant HCN4-KCNE1 Channel Complex Depends on the KCNE1-G38S Polymorphism.

Archiv der Pharmazie - 1 Jun 2026

Linhoff David, Mertens Minay, Zimmermann Ricarda, Peischard Stefan, Brenker Christoph, Budde Thomas, Meuth Sven, Gatsogiannis Christos, Lüttjohann Annika, Sosulina Liudmila, Hescheler Jürgen, Strutz-Seebohm Nathalie, Seebohm Guiscard

Abstract excerpt

The sinoatrial node pacemaker channel HCN4 plays a central role in cardiac automaticity, and disease-associated variants can predispose to atrial arrhythmias. Here, we investigated the functional interplay between the HCN4 variant P883R and the potassium channel β-subunit KCNE1, focusing on the common atrial fibrillation-associated KCNE1 variant G38S and its regulation by the iron-induced serine protease TMPRSS6....

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Share to Atrial Fibrillation
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

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Identifiers

PMID: 42424558
DOI: 10.1002/ardp.70303
PMCID: PMC13349338

Genes

HCN4
TMPRSS6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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