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TMPRSS6 cleaves KCNE1 and causes arrhythmias in iron overload disease

2024-09-10

Abstract excerpt

Iron storage disease is associated with cardiovascular manifestations, including various forms of cardiac arrhythmias of unknown origin. In this study, cardiac arrhythmias associated with iron overload were investigated in human iPSC-derived cardiomyocytes (hiPSC-CM) and hiPSC-derived sinus node-like pacemaker cells. Among other effects, iron overload leads to an increase in the plasma membrane-anchored protease T...

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Literature Corpus work
e571afd1-eb10-5575-a603-d6b9e2fdb302
DOI
10.1101/2024.09.04.611322
Open publication

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TMPRSS6 cleaves KCNE1 and causes arrhythmias in iron overload diseaseDOI 10.1101/2024.09.04.611322
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