The Sex-Stratified Effects of RSPO3 Expression on Body Fat and Blood Lipids: An Omics Mendelian Randomization Study.

doi:10.1002/oby.70252

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Article

The Sex-Stratified Effects of RSPO3 Expression on Body Fat and Blood Lipids: An Omics Mendelian Randomization Study.

Obesity (Silver Spring, Md.) - 1 Aug 2026

Guo Yihua, Chen Zhihe, Huang Lanhui, Zhang Zhongyun, Gong Yujia, Yang Qian, Wang Jiqiu, Zheng Jie

Abstract excerpt

OBJECTIVE: This study examined sex-stratified effects of R-spondin 3 (RSPO3) expression levels on body fat and blood lipids and their potential mediation effects through sex hormones. METHODS: We performed a sex-stratified genome-wide association study (GWAS) of RSPO3 protein (N = 18,529 men and 21,323 women). We used two-sample Mendelian randomization (MR) to examine associations of RSPO3 expression with the...

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Identifiers

PMID: 42420700
DOI: 10.1002/oby.70252
PMCID: PMC13422653

Genes

RSPO3

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PubMed metadata and Literature Corpus relationships.