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Article

DNA Methylation, SERPING1 Expression, and Immune-related Traits in Osteoporosis: A Mendelian Randomization Study And Supportive Ex Vivo Evidence.

Endocrine, metabolic & immune disorders drug targets - 1 Jan 2026

Chen Shangtong, Xia Tian, Huang Chuanhong

Abstract excerpt

INTRODUCTION: Osteoporosis (OP) is a major public health burden; however, the role of SERPIN family proteins remains incompletely understood. This study aimed to investigate genetically inferred associations between SERPINs and OP and to explore potential regulatory relationships. METHODS: Genome-wide association study (GWAS) summary statistics were used to perform two-sample Mendelian randomization (MR) and...

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Topics

Humans
Osteoporosis
DNA Methylation
Mendelian Randomization Analysis
Serpins
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Female

Complement C1 Inhibitor Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 41832983
DOI: 10.2174/0118715303462423260125161230
PMCID: PMC13598738

Genes

SERPING1

Provenance

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