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Resolution-Aware Eight-Locus HLA Diversity Profiling and Rare Allele Interpretation in an Eastern Chinese Transplant-Typing Cohort.

HLA - 1 Jul 2026

Yuan Chao, Wang Ning, Yuan Fenghua, Zhao Yan, Wang Xiaoyan

Abstract excerpt

HLA diversity profiling is essential for transplant-typing practice, yet its interpretation is complicated by heterogeneous typing resolution and ambiguity in routine clinical datasets. We analysed eight-locus HLA genotyping results from 1388 individuals in an Eastern Chinese transplant-typing cohort (2021-2026) using a resolution-aware two-stage analytical framework-an approach that explicitly distinguishes...

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Cohort Studies
East Asian People
Genetic Loci
Heterozygote
Histocompatibility Testing

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PMID: 42409602
DOI: 10.1111/tan.70848
PMCID: PMC13349695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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