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Development of a CRISPR/dCas9-based membrane-assisted colorimetric assay for detection of high-risk HPV16 and HPV18: a proof-of-concept study.

Molecular biology reports - 4 Jul 2026

Tamrakar Vaibhav Kumar, Sharma Kuldeep, Singh Pushpendra, Bhargava Anudita, Thakur Pushpawati, Negi Sanjay Singh

Abstract excerpt

BACKGROUND AND AIMS: Persistent infection with high-risk human papillomavirus (HR-HPV), particularly HPV16 and HPV18, is the leading cause of cervical cancer. While molecular diagnostics offer high sensitivity, their deployment in decentralized settings remains limited. This study presents a proof-of-concept CRISPR/dCas9-based membrane-assisted detection platform for HR-HPV genotyping. METHODS: A membrane-based...

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Colorimetry
CRISPR-Cas Systems
Genotyping Techniques
Human papillomavirus 16
Human papillomavirus 18

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Papillomavirus Infections

Proof of Concept Study

Sensitivity and Specificity

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PMID: 42400669
DOI: 10.1007/s11033-026-12309-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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