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Development and evaluation of a CRISPR/Cas12a-based diagnostic test for rapid detection and genotyping of HR-HPV in clinical specimens.

Microbiology spectrum - 7 Jan 2025

Yin Lijuan, Zhao Ziqian, Wang Chunhua, Zhou Caihong, Wu Xiuzhen, Gao Baoxue, Wang Liangyuan, Man Shuli, Cheng Xinkuan, Wu Qiankun, Hu Siqi, Fan Hongxia, Ma Long, Xing Hui, Shen Liang

Abstract excerpt

Persistent infection with high-risk human papillomavirus (HR-HPV) is the principal etiological factor of cervical cancer. Considering the gradual progression of cervical cancer, the early, rapid, sensitive, and specific identification of HPV, particularly HR-HPV types, is crucial in halting the advancement of the illness. Here, we established a rapid, highly sensitive, and specific HR-HPV detection platform,...

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Identifiers

PMID: 39570020
DOI: 10.1128/spectrum.02253-24
PMCID: PMC11705848

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