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Article

Rapid detection of HPV16/18 based on a CRISPR-Cas13a/Cas12a dual-channel system

1 Jan 2022

Abstract excerpt

PURPOSE: cervical cancer is the leading cause of cancer deaths in women in the developing world, with high-risk HPV16 and HPV18 accounting for approximately 70% of all cervical cancers. Early detection of HPV, especially high-risk HPV types, is essential to prevent disease progression. METHODS: in this study, we established a highly sensitive and specific nucleic acid assay based on a CRISPR-Cas13a/Cas12a...

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PMID: 36449008
DOI: 10.1039/d2ay01536f

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