Article
Social isolation, loneliness, genetic susceptibility, and the risk of hypothyroidism.
Social neuroscience - 1 Aug 2026
Zhang Juanjuan, Bonnet Fabrice, Liu Yulu, Ji Chao, He Yuerong, Shen Jiale, Yang Honghao, Chang Qing, Zhao Yuhong, Guo Zhuohan, Chen Liangkai, Liu Li, Xia Yang
Abstract excerpt
This study aimed to explore associations between social isolation, loneliness, and hypothyroidism risk, and whether genetic susceptibility modifies these links. It enrolled 434,628 hypothyroidism-free participants from the UK Biobank. Social isolation was assessed via 3 dichotomous questions, loneliness via 2 revised UCLA Loneliness Scale questions, and hypothyroidism cases via hospital/death records....
Read the complete abstract on PubMedTopics
- Humans
- Social Isolation
- Loneliness
- Hypothyroidism
- Genetic Predisposition to Disease
- Female