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Loneliness, traditional risk factor control, genetic predisposition, and development of musculoskeletal disorders.

Rheumatology (Oxford, England) - 30 Jun 2026

Ma Xiaofeng, Song Xin, Zou Yanqiu, Zhang Di, Yang Bin, Lei Bowen, Zhou Jinyu, Zhao Xunying, Xiang Rong, Qu Yang, Zheng Sirui, Yu Ting, Han Tao, Zhong Yangdan, Xia Maoyao, Fan Mengyu, Jiang Xia, Zhang Ben

Abstract excerpt

OBJECTIVES: The objectives of this study were to investigate prospective associations of loneliness and social isolation with musculoskeletal (MSK) disorder risk, to evaluate their relative importance relative to that of traditional risk factors, and assess interactions with genetic predispositions. METHODS: We analysed data from 315 197 UK Biobank participants. Loneliness and social isolation were assessed...

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Identifiers

PMID: 42360795
DOI: 10.1093/rheumatology/keag326
PMCID: PMC13394693

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