Targeted Analysis of Cell-free Circulating Tumor DNA is Suitable for Early Relapse and Actionable Target Detection in Patients with Neuroblastoma.

doi:10.1158/1078-0432.CCR-21-3716

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Targeted Analysis of Cell-free Circulating Tumor DNA is Suitable for Early Relapse and Actionable Target Detection in Patients with Neuroblastoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 2 May 2022

Lodrini Marco, Graef Josefine, Thole-Kliesch Theresa M, Astrahantseff Kathy, Sprüssel Annika, Grimaldi Maddalena, Peitz Constantin, Linke Rasmus B, Hollander Jan F, Lankes Erwin, Künkele Annette, Oevermann Lena, Schwabe Georg, Fuchs Jörg, Szymansky Annabell, Schulte Johannes H, Hundsdörfer Patrick, Eckert Cornelia, Amthauer Holger, Eggert Angelika, Deubzer Hedwig E

Abstract excerpt

PURPOSE: Treating refractory or relapsed neuroblastoma remains challenging. Monitoring body fluids for tumor-derived molecular information indicating minimal residual disease supports more frequent diagnostic surveillance and may have the power to detect resistant subclones before they give rise to relapses. If actionable targets are identified from liquid biopsies, targeted treatment options can be considered...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell-Free Nucleic Acids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child

Share to Circulating Tumor DNA

Share to Mutation

Share to N-Myc Proto-Oncogene Protein

Share to Neoplasm Recurrence, Local

Share to Neuroblastoma

Share to Receptor Protein-Tyrosine Kinases

Source

Open in PubMed

Identifiers

PMID: 35247920
DOI: 10.1158/1078-0432.CCR-21-3716

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted Analysis of Cell-free Circulating Tumor DNA is Suitable for Early Relapse and Actionable Target Detection in Patients with Neuroblastoma.PMID 35247920Read ↗

Neuroblastoma Molecular Risk-Stratification of DNA Copy Number and ALK Genotyping via Cell-Free Circulating Tumor DNA ProfilingSemantic proximity Read ↗

Detection of Targetable Genetic Abnormalities in Neuroblastoma Circulating Tumour DNA.Semantic proximity Read ↗

Using droplet digital PCR to analyzeMYCNandALKcopy number in plasma from patients with neuroblastomaSemantic proximity Read ↗

Serially Quantifying TERT Rearrangement Breakpoints in ctDNA Enables Minimal Residual Disease Monitoring in Patients with NeuroblastomaSemantic proximity Read ↗

Cell-Free RNA from Plasma in Patients with Neuroblastoma: Exploring the Technical and Clinical PotentialSemantic proximity Read ↗

A Targeted Gene Panel for Circulating Tumor DNA Sequencing in NeuroblastomaSemantic proximity Read ↗

Epigenetic Liquid Biopsy Enables Universal Mutation-Agnostic Molecular Surveillance for High-Risk NeuroblastomaSemantic proximity Read ↗

Multiplexed Quantification of Four Neuroblastoma DNA Targets in a Single Droplet Digital PCR Reaction.Semantic proximity Read ↗

Whole-Exome Sequencing of Cell-Free DNA Reveals Temporo-spatial Heterogeneity and Identifies Treatment-Resistant Clones in Neuroblastoma.Semantic proximity Read ↗

Simultaneous Ultra-Sensitive Detection of Structural and Single Nucleotide Variants Using Multiplex Droplet Digital PCR in Liquid Biopsies from Children with MedulloblastomaSemantic proximity Read ↗

Whole-genome informed circulating tumor DNA analysis by multiplex digital PCR for disease monitoring in B-cell lymphomas: a proof-of-concept studySemantic proximity Read ↗

Droplet digital PCR-based detection of circulating tumor DNA from pediatric high grade and diffuse midline glioma patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.