Krüppel-Like Factor 5 Inhibition Rescues Cavernous Nerve-Injured Erectile Dysfunction by Preventing Phenotypic Switch and Mitochondrial Dysfunction-Dependent Apoptosis in Corpus Cavernosum Smooth Muscle Cells.

Abstract excerpt

Phenotypic switch and apoptosis of corpus cavernosum smooth muscle cells (CCSMCs) contribute to cavernous nerve injury (CNI)-induced erectile dysfunction (CNI-ED). Krüppel-like factor 5 (KLF5) has been identified as a regulator of smooth muscle cell phenotype and apoptosis. Nevertheless, its function in CNI-ED remains unclarified. This work sought to investigate the involvement of KLF5 in a CNI-ED rat model....

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• Apoptosis
• Erectile Dysfunction
• Kruppel-Like Transcription Factors
• Mitochondria
• Myocytes, Smooth Muscle