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Article

Prognostic impact of circulating tumor DNA detection in portal and peripheral blood in resected pancreatic ductal adenocarcinoma patients.

Scientific reports - 8 Nov 2024

Maulat Charlotte, Canivet Cindy, Cabarrou Bastien, Pradines Anne, Selves Janick, Casanova Anne, Doussine Aurélia, Hanoun Naïma, Cuellar Emmanuel, Boulard Paul, Carrère Nicolas, Buscail Louis, Bournet Barbara, Muscari Fabrice, Cordelier Pierre

Abstract excerpt

In PDAC patients, ctDNA detection's prognostic significance needs validation especially in resected patients. This study investigated ctDNA kinetics in portal and peripheral blood before and after resection, and whether tissue mobilization during surgery influences ctDNA detection. In this single-center prospective cohort, portal and peripheral blood were drawn during pancreaticoduodenectomy before and after...

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Identifiers

PMID: 39516243
DOI: 10.1038/s41598-024-76903-y
PMCID: PMC11549393

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