Article
Integrated genomic and immunophenotypic profiling reveals monoclonal origin, smoking-driven evolution and heterogeneous microenvironment in pulmonary adenosquamous carcinoma.
Frontiers in immunology - 1 Jan 2026
Zhang Xiuwen, Wu Heng, Zhao Wenhao, Hu Zixuan, Wang Guannan, Li Yongwen, Li Xuanguang, Zhang Hongbing, Liu Minghui, Chen Chen, Liu Jinghao, Zhou Wenhao, Liu Hongyu, Chen Jun
Abstract excerpt
Background: Pulmonary adenosquamous carcinoma (ASC) is a rare, aggressive subtype of non-small cell lung cancer (NSCLC), characterized by both adenocarcinoma (ACC) and squamous cell carcinoma (SCCC) components. Due to its rarity, the clonal origin, evolutionary drivers, and tumor microenvironment (TME) of ASC remain poorly understood. Methods: We conducted clinical and prognostic analyses on 76 ASC patients. Nine...
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