Article
Molecular profiling of breast cancer pleural effusions using cytology specimens: Impact of sample source and cytological features on next-generation sequencing performance.
Cancer cytopathology - 1 Jul 2026
Virk Harpreet, Michael Claire, Pfeil Keri Ann, Sadri Navid, Bomeisl Philip, Harbhajanka Aparna
Abstract excerpt
BACKGROUND: Malignant effusions in breast cancer are a minimally invasive source for molecular profiling. Effusion-derived cytology specimens, cell blocks (CB) and post-ThinPrep PreservCyt (PTPC) supernatant, are reliable sources for molecular testing but differ in DNA concentration and turnaround time (TAT). This study evaluates mutational profiles, cytology characteristics, and clinical correlates to assess the...
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