Article
Targeted deep sequencing of effusion cytology samples is feasible, informs spatiotemporal tumor evolution, and has clinical and diagnostic utility.
Genes, chromosomes & cancer - 1 Feb 2018
Leichsenring Jonas, Volckmar Anna-Lena, Kirchner Martina, Kazdal Daniel, Kriegsmann Mark, Stögbauer Fabian, Bockmayr Teresa, Klauschen Frederick, Herth Felix J F, Penzel Roland, Warth Arne, Schirmacher Peter, Endris Volker, Stenzinger Albrecht
Abstract excerpt
During the course of disease, many cancer patients eventually present with metastatic disease including peritoneal or pleural spread. In this context, cytology specimens derived from ascites or pleural effusion may help to differentiate malignant from benign conditions and sometimes yield diagnosis of a malignancy. However, even when supported by immunohistochemistry, cytological interpretation can be...
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