Germline Variation in Notch Pathway and Survival After Androgen Deprivation Therapy in Prostate Cancer: Implicating YAP1 rs1894116 and Focal Adhesion Signaling.

Abstract excerpt

BACKGROUND/AIM: Notch signaling exerts context-dependent effects in cancer; however, the prognostic relevance of inherited variation in Notch-related genes in prostate cancer remains unclear. We investigated whether germline single-nucleotide polymorphisms (SNPs) in Notch pathway genes are associated with clinical outcomes in men receiving androgen deprivation therapy (ADT). PATIENTS AND METHODS: We genotyped 222...

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