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Article

Insights Into the Susceptibility of Fungal Infection and STAT3 Genetic Mutations.

Mycoses - 1 Jul 2026

Li Fengming, Liu Xiaodong, Li Yuanyuan, Wu Jie, Dang Ningning, Guo Jing

Abstract excerpt

Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor that regulates a spectrum of genes and signalling pathways critical for the antifungal immune response. Mutations in the STAT3 gene confer susceptibility to severe and recurrent fungal infections, predominantly via disruption of interleukin-17 (IL-17)-mediated immunity. This review synthesises current mechanistic insights...

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Identifiers

PMID: 42370716
DOI: 10.1111/myc.70200
PMCID: PMC13312899

Genes

STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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