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Article

Human defects in STAT3 promote oral mucosal fungal and bacterial dysbiosis.

JCI insight - 6 Sept 2018

Abusleme Loreto, Diaz Patricia I, Freeman Alexandra F, Greenwell-Wild Teresa, Brenchley Laurie, Desai Jigar V, Ng Weng-Ian, Holland Steven M, Lionakis Michail S, Segre Julia A, Kong Heidi H, Moutsopoulos Niki M

Abstract excerpt

Studies in patients with genetic defects can provide unique insights regarding the role of specific genes and pathways in humans. Patients with defects in the Th17/IL-17 axis, such as patients harboring loss-of-function STAT3 mutations (autosomal-dominant hyper IgE syndrome; AD-HIES) present with recurrent oral fungal infections. Our studies aimed to comprehensively evaluate consequences of STAT3 deficiency on...

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Identifiers

PMID: 30185668
DOI: 10.1172/jci.insight.122061
PMCID: PMC6171814

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