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Article

Mendelian traits causing susceptibility to mucocutaneous fungal infections in human subjects.

The Journal of allergy and clinical immunology - 1 Feb 2012

Engelhardt Karin R, Grimbacher Bodo

Abstract excerpt

Mucocutaneous candidiasis and dermatophyte infections occur either in isolation or alongside other symptoms in patients with various primary immunodeficiency diseases with diverse genetic defects, which result in impaired IL-17 immunity, IL-22 immunity, or both. In patients with chronic mucocutaneous candidiasis, disease-associated polymorphisms in DECTIN1 act on the level of fungal recognition, whereas mutations...

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Source

Identifiers

PMID: 22284928
DOI: 10.1016/j.jaci.2011.12.966

Genes

CARD9
BCL10
MALT1
STAT1
STAT3

Provenance

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