Article
Skin microbiome imbalance in patients with STAT1/STAT3 defects impairs innate host defense responses.
Journal of innate immunity - 1 Jan 2014
Smeekens Sanne P, Huttenhower Curtis, Riza Anca, van de Veerdonk Frank L, Zeeuwen Patrick L J M, Schalkwijk Joost, van der Meer Jos W M, Xavier Ramnik J, Netea Mihai G, Gevers Dirk
Abstract excerpt
BACKGROUND: Chronic mucocutaneous candidiasis (CMC) and hyper-IgE syndrome (HIES) are primary immunodeficiencies mainly caused by mutations in STAT1 and STAT3, respectively. CMC and HIES patients have an increased risk for skin and mucosal infections with fungal pathogens and Staphylococcus aureus. However, it is unknown whether the genetic defects in these patients also affect the skin and mucosal microbiome,...
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