Article
Molecular mechanisms of mucocutaneous immunity against Candida and Staphylococcus species.
The Journal of allergy and clinical immunology - 1 Nov 2012
Maródi László, Cypowyj Sophie, Tóth Beáta, Chernyshova Liudmyla, Puel Anne, Casanova Jean-Laurent
Abstract excerpt
Signal transducer and activator of transcription (STAT) proteins are key components of the innate and adaptive immune responses to pathogenic microorganisms. Recent research on primary immunodeficiency disorders and the identification of patients carrying germline mutations in STAT1, STAT3, and STAT5B have highlighted the role of human STATs in host defense against various viruses, bacteria, and fungi. Mutations...
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