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Article

Causal Effects of Gut Microbiota and Metabolites on Chronic Obstructive Pulmonary Disease: A Bidirectional Two Sample Mendelian Randomization Study.

International journal of chronic obstructive pulmonary disease - 1 Jan 2024

Du Yongkun, Wang Shuai, Zhou Ting, Zhao Zhongyan

Abstract excerpt

Background: Recent evidence suggests that the gut microbiome and metabolites are intricately involved in Chronic Obstructive Pulmonary Disease (COPD) pathogenesis, yet the precise causal relationships remain unclear due to confounding factors and reverse causation. This study employs bidirectional two-sample Mendelian Randomization (MR) to clarify these connections. Methods: Summary data from publicly available...

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Identifiers

PMID: 39360021
DOI: 10.2147/COPD.S472218
PMCID: PMC11446199

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