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Article

β2-Microglobulin Induces Mitochondrial Dysfunction Accompanied by Bronchial Epithelial Cell Senescence.

International journal of chronic obstructive pulmonary disease - 1 Jan 2026

Gu Yu, Yuan Wei, Xie Xue-Fei, Dong Hong-Meng, Wei Bing, Wang Jun-Yu

Abstract excerpt

Purpose: β2-microglobulin (β2m) is the light-chain subunit of major histocompatibility complex class I (MHC I) molecules. Our group previously showed that β2m contributes to emphysema development by inducing epithelial cell senescence. However, the mechanism linking β2m to epithelial senescence remains unclear. Previous studies have reported mitochondrial dysfunction in senescent lung cells from patients with...

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Identifiers

PMID: 42367344
DOI: 10.2147/COPD.S614376
PMCID: PMC13295159

Genes

CCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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