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Article

Social Disconnection, Genetic Risk, and the Incidence of Degenerative Valvular Heart Disease: A Population-Based Cohort Study.

Journal of the American Heart Association - 21 Apr 2026

Cao Chenghui, Wei Cheng, Gong Wen, Yu Bilian, Fang Zhenfei, Zhou Shenghua, Zhu Zhaowei

Abstract excerpt

BACKGROUND: Degenerative valvular heart disease (VHD) is increasingly recognized as a major public health concern in aging populations. Although traditional cardiovascular risk factors have been extensively investigated, the role of loneliness and social isolation has remained largely overlooked in the context of valvular pathology. METHODS: We conducted a prospective cohort study involving 462 917 participants...

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Identifiers

PMID: 41983291
DOI: 10.1161/JAHA.125.045931
PMCID: PMC13279164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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