Article
A Bidirectional Mendelian Randomization Study to evaluate the causal role of reduced blood vitamin D levels with type 2 diabetes risk in South Asians and Europeans.
Nutrition journal - 27 Jul 2021
Bejar Cynthia A, Goyal Shiwali, Afzal Shoaib, Mangino Massimo, Zhou Ang, van der Most Peter J, Bao Yanchun, Gupta Vipin, Smart Melissa C, Walia Gagandeep K, Verweij Niek, Power Christine, Prabhakaran Dorairaj, Singh Jai Rup, Mehra Narinder K, Wander Gurpreet S, Ralhan Sarju, Kinra Sanjay, Kumari Meena, de Borst Martin H, Hyppönen Elina, Spector Tim D, Nordestgaard Børge G, Blackett Piers R, Sanghera Dharambir K
Abstract excerpt
CONTEXT: Multiple observational studies have reported an inverse relationship between 25-hydroxyvitamin D concentrations (25(OH)D) and type 2 diabetes (T2D). However, the results of short- and long-term interventional trials concerning the relationship between 25(OH)D and T2D risk have been inconsistent. OBJECTIVES AND METHODS: To evaluate the causal role of reduced blood 25(OH)D in T2D, here we have performed a...
Topics
- Asian People
- Diabetes Mellitus, Type 2
- Humans
- Mendelian Randomization Analysis
- Polymorphism, Single Nucleotide
- Vitamin D
- Vitamin D Deficiency