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Article

Integrative Analysis of Oxidative Stress and Cellular Senescence Pathways in Chronic Obstructive Pulmonary Disease.

Genes - 10 Jun 2026

Timasheva Yanina, Korytina Gulnaz, Markelov Vitaly, Nasibullin Timur, Akhmadishina Leysan, Aznabaeva Yulia, Zulkarneev Shamil, Kochetova Olga, Zagidullin Naufal

Abstract excerpt

Background/Objectives: Chronic obstructive pulmonary disease (COPD) is increasingly viewed as a disorder of impaired cellular adaptation to chronic stress, involving oxidative injury, mitochondrial dysfunction, and accelerated cellular senescence. We investigated whether genetic variation in these pathways contributes to disease susceptibility, lung function impairment, and polygenic risk prediction. Methods:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42353844
DOI: 10.3390/genes17060685
PMCID: PMC13299048

Genes

NFE2L2
CDKN2B
GSR
HMOX1
PTEN
SIRT3
TOMM40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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