Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Blood-Based Epigenetic Aging Signatures in D3GHR Carriers: An Exploratory Pilot Study of Metabolic Adaptation and Aging-Related Pathways.

International journal of molecular sciences - 8 Jun 2026

Berger Ori, Insler Maayan, Falah Ghadeer, Ben David Gil, Sharvit Lital, Springer Shmuel, Talisman Ran, Atzmon Gil

Abstract excerpt

The exon 3 deletion polymorphism in the growth hormone receptor gene (d3GHR) is associated with altered GH signaling and longevity-related phenotypes, yet its relationship with blood-based epigenetic aging remains unclear. We analyzed whole-blood DNA from 21 unrelated adults recruited at Laniado Medical Center to determine whether the d3GHR genotype was associated with differential DNA methylation in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological
Share to Aging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Pilot Projects

Share to Promoter Regions, Genetic

Share to Receptors, Somatotropin

Source

Open in PubMed Open full text

Identifiers

PMID: 42352906
DOI: 10.3390/ijms27125181
PMCID: PMC13299114

Genes

ACAT2
CYP1A1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Blood-Based Epigenetic Aging Signatures in D3GHR Carriers: An Exploratory Pilot Study of Metabolic Adaptation and Aging-Related Pathways.PMID 42352906Read ↗

Exploring multi-omics and clinical characteristics linked to accelerated biological aging in Asian women of reproductive age: insights from the S-PRESTO study.Semantic proximity Read ↗

The d3GHR carrier epigenome in Druze clan longevity.Semantic proximity Read ↗

Associations of Body Composition and Physical Activity Level With Multiple Measures of Epigenetic Age AccelerationSemantic proximity Read ↗

Molecular Aging of Human Liver: An Epigenetic/Transcriptomic SignatureSemantic proximity Read ↗

Sex-specific phenotypic effects and evolutionary history of an ancient polymorphic deletion of the human growth hormone receptorSemantic proximity Read ↗

A genome-wide association study identifies Asian-specific genetic susceptibility for epigenetic age acceleration.Semantic proximity Read ↗

A meta-analysis of genome-wide association studies of epigenetic age acceleration.Semantic proximity Read ↗

The influences of DNA methylation and epigenetic clocks, on metabolic disease, in middle-aged Koreans.Semantic proximity Read ↗

Epigenetic clocks derived from western samples differentially reflect Taiwanese health outcomesSemantic proximity Read ↗

The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature.Semantic proximity Read ↗

Interaction Among Sex, Aging, and Epigenetic Processes Concerning Visceral Fat, Insulin Resistance, and DyslipidaemiaSemantic proximity Read ↗

Investigation of bidirectional longitudinal associations between advanced epigenetic age and peripheral biomarkers of inflammation and metabolic syndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.