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Article

Mechanisms of and risk factors for in vivo evolution of carbapenem resistance in Pseudomonas aeruginosa causing lower respiratory tract infections.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Sept 2026

Xiao Shuzhen, Jian Zijuan, Yang Kun, Zhao Shengyuan

Abstract excerpt

OBJECTIVES: To elucidate the molecular mechanisms and epidemiological risk factors driving the in vivo evolution from carbapenem-susceptible Pseudomonas aeruginosa (CSPA) to carbapenem-resistant PA (CRPA). METHODS: We conducted a retrospective cohort study among inpatients with PA lower respiratory tract infections (LRTIs) in a tertiary care teaching hospital from 2021 to 2023. Consecutive inpatients who...

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Carbapenems
Drug Resistance, Bacterial
Microbial Sensitivity Tests
Pseudomonas aeruginosa
Pseudomonas Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Respiratory Tract Infections

Virulence Factors

Whole Genome Sequencing

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PMID: 42349779
DOI: 10.1016/j.ijid.2026.108935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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