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Article

Development and Analytical Validation of a Laboratory-Customized TaqMan-MGB Probe Method for CYP2C19 Genotyping.

Journal of clinical laboratory analysis - 1 Aug 2026

Liu Yaqun, Chen Lianghui, Zheng Xuanyi, Yang Peikui, Chen Yicun, Xie Chengsong, Zhang Zhenxia, Zheng Yuzhong

Abstract excerpt

BACKGROUND: Genetic polymorphisms in CYP2C19 influence the metabolism of multiple clinically important drugs. Although TaqMan-based genotyping of CYP2C19*2 and CYP2C19*17 is well established, open and locally implementable workflows remain useful for laboratory validation and application. This study aimed to develop and analytically validate a laboratory-customized, open-sequence TaqMan-MGB assay for detecting...

Read the complete abstract on PubMed

Topics

Cytochrome P-450 CYP2C19
Humans
Genotyping Techniques
Reproducibility of Results
Genotype
Limit of Detection

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 42385188
DOI: 10.1002/jcla.70296
PMCID: PMC13399776

Genes

CYP2C19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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