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Article

Phenotypic heterogeneity optimizes trade-offs during adaptive deployment of the type VI secretion system.

PLoS biology - 1 Jun 2026

Taillefer Boris, Schattenberg Florian, Doan Thierry, Müller Susann, Cascales Eric

Abstract excerpt

The type VI secretion system (T6SS) is a widespread nanoweapon deployed by bacteria to eliminate competitors in polymicrobial environments, allowing niche colonization or host invasion. Fluorescence microscopy recordings have shown that T6SS expression and/or activation is heterogeneous in clonal populations of many bacterial species. However, it is still unknown whether T6SS heterogeneity is genetically...

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PMID: 42241453
DOI: 10.1371/journal.pbio.3003838
PMCID: PMC13262931

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