Article
Discovery of a mutation-containing circRNA in polyglutamine disease through systematic analysis of RNAs with CAG repeats.
RNA biology - 1 Dec 2026
Pawlik Weronika, Woźna-Wysocka Magdalena, Jazurek-Ciesiołka Magdalena, Dulski Jarosław, Witkoś Tomasz M, Ciołak Agata, Kozłowska Emilia, Kościańska Edyta, Bartelt Luke C, Philippe Julien, Sławek Jarosław, Świtoński Paweł M, La Spada Albert R, Fiszer Agnieszka
Abstract excerpt
CAG repeat tracts occur in both non-coding and translated RNAs, have tended to lengthen throughout evolution, and are thought to enhance neuronal function. We identified over 600 human RNAs (including mRNAs, lncRNAs, and circRNAs) with at least 10 CAG repeats, originating from 58 genomic loci, which vary, e.g. in the rate of CAG length polymorphism. Several circRNAs originate from the ATXN7 locus, where CAG...
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