Article

Overview of non-coding RNAs with CAG repeats and the case of mutation-containing circRNA in polyglutamine disease patients

2025-08-13

Abstract excerpt

CAG trinucleotide repeats are present in protein-coding and non-coding RNAs (ncRNAs). They are polymorphic in length and can cause neurodegenerative diseases when expanded, e.g., spinocerebellar ataxia type 7 (SCA7) is caused by a mutation in the ATXN7 gene. We focused on RNAs with at least 10 CAG repeats and identified several hundred mRNAs, long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) originatin...

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Literature Corpus work: e17bf7ae-cb5c-554f-b952-73e1dab6ae95
DOI: 10.1101/2025.08.13.669846

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