Article
Reference-free clustering as an epidemiological tool for Mycobacterium tuberculosis lineage typing.
Microbial genomics - 1 Jun 2026
Chilengue Aureliana F C, Whiley Daniel J, Cox Kate, Domingo-Sananes Maria Rosa, Meehan Conor J
Abstract excerpt
Whole-genome sequencing (WGS) of Mycobacterium tuberculosis (Mtb) is widely used in epidemiological investigations of recent transmission events, resulting in high-resolution strain typing. Accurate and rapid strain typing is essential for informing outbreak investigations and guiding tuberculosis control strategies. However, the gold-standard reference-guided SNP-calling pipeline currently used for strain typing...
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