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Comparison of in silico predicted Mycobacterium tuberculosis spoligotypes and lineages from whole genome sequencing data.

Scientific reports - 13 Jul 2023

Napier Gary, Couvin David, Refrégier Guislaine, Guyeux Christophe, Meehan Conor J, Sola Christophe, Campino Susana, Phelan Jody, Clark Taane G

Abstract excerpt

Bacterial strain-types in the Mycobacterium tuberculosis complex underlie tuberculosis disease, and have been associated with drug resistance, transmissibility, virulence, and host-pathogen interactions. Spoligotyping was developed as a molecular genotyping technique used to determine strain-types, though recent advances in whole genome sequencing (WGS) technology have led to their characterization using...

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PMID: 37443186
DOI: 10.1038/s41598-023-38384-3
PMCID: PMC10345134

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Source receipt: pubmed, retrieved 7 Sept 2026.

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