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Article

Skin eQTL-Cerebrospinal Fluid Metabolites-Keloid Axis: An Integrative Multi-Omics Mediation Mendelian Randomization Study.

Chemical biology & drug design - 1 Jun 2026

Xu Jie, Bai Mengqi, Liu Tongyun

Abstract excerpt

Keloids are fibroproliferative dermal disorders characterized by excessive extracellular matrix deposition and a strong tendency to recur, yet the mechanistic links between inherited genetic variation, molecular phenotypes and disease risk remain incompletely understood. We integrated GTEx v8 skin expression quantitative trait loci (eQTL) data, pooled GWAS statistics for 338 cerebrospinal fluid (CSF) metabolites,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42338145
DOI: 10.1111/cbdd.70346

Genes

ALDH2
PARP14
COL1A1
COL3A1
FN1
POSTN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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