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CTHRC1+ fibroblasts are stimulated by macrophage‐secreted SPP1 to induce excessive collagen deposition in keloids

1 Dec 2022

Abstract excerpt

Dear Editor, Fibrosis is characterized by fibroblast dysfunction and excessive deposition of cell-matrix that affect the normal functioning of the original tissue or organ.1 The pathogenesis of keloids is complex and remains elusive. Multiple studies have suggested that skin color and tension,2 immunity,3 hormones, inflammatory stimulation,4 genes5 and other factors play critical roles in the onset and...

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PMID: 36480415
DOI: 10.1002/ctm2.1115

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