Article
Association of Fetal Gene Regulatory Gene Deletions With Poor Cognition in Schizophrenia and Community-Based Samples.
The American journal of psychiatry - 1 Aug 2026
Forsyth Jennifer K, Zhu Jinhan, Chavannes Ariana S, Trevorrow Zachary H, Hyat Mahnoor, Sievertsen Sam A, Ferreira-Ianone Sophie, Conomos Matthew P, Nuechterlein Keith H, Asarnow Robert F, Green Michael F, Karlsgodt Katherine H, Perkins Diana O, Cannon Tyrone D, Addington Jean M, Cadenhead Kristen S, Cornblatt Barbara A, Keshavan Matcheri S, Mathalon Daniel H, Stone William S, Tsuang Ming T, Walker Elaine F, Woods Scott W, Narr Katherine L, McEwen Sarah C, Schleifer Charles H, Yee Cindy M, Diehl Caroline K, Guha Anika, Miller Gregory A, Alexander-Bloch Aaron F, Sha Zhiqiang, Glessner Joseph, Seidlitz Jakob, Bethlehem Richard A I, Ophoff Roel A, Bearden Carrie E
Abstract excerpt
OBJECTIVE: Schizophrenia is a neurodevelopmental disorder involving clinical and genetic heterogeneity. Multiple recurrent copy number variants (CNVs) increase risk for schizophrenia spectrum disorders (SSDs). However, it is unclear how known risk CNVs and broader genome-wide CNVs influence clinical variability. Furthermore, whether biological annotation of CNV scores can improve power for patient stratification...
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