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Article

Maternal Abdominal Obesity and Hirschsprung's Disease in Offspring: A Two-Sample Mendelian Randomization Study.

The Journal of surgical research - 1 Sept 2026

Wang Yun-Jin, Fang Yi-Fan, Xie Si-Qi, Cui Xu, Zhang Jian-Qin, Chen Liu, Guan Guo-Xian

Abstract excerpt

INTRODUCTION: The study aimed to explore the causal effect of pre-pregnancy waist-to-hip ratio adjusted for body mass index (WHRadjBMI) on Hirschsprung's disease (HD) in offspring. MATERIALS AND METHODS: Genome-wide association data for WHRadjBMI and HD were obtained from the Mendelian randomization (MR) base platform. Significant single nucleotide polymorphisms associated with WHRadjBMI in females were...

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Identifiers

PMID: 42335627
DOI: 10.1016/j.jss.2026.05.039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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