Article
Frequent somatic CDH1 loss-of-function mutations in plasmacytoid variant bladder cancer.
Nature genetics - 1 Apr 2016
Al-Ahmadie Hikmat A, Iyer Gopa, Lee Byron H, Scott Sasinya N, Mehra Rohit, Bagrodia Aditya, Jordan Emmet J, Gao Sizhi Paul, Ramirez Ricardo, Cha Eugene K, Desai Neil B, Zabor Emily C, Ostrovnaya Irina, Gopalan Anuradha, Chen Ying-Bei, Fine Samson W, Tickoo Satish K, Gandhi Anupama, Hreiki Joseph, Viale Agnès, Arcila Maria E, Dalbagni Guido, Rosenberg Jonathan E, Bochner Bernard H, Bajorin Dean F, Berger Michael F, Reuter Victor E, Taylor Barry S, Solit David B
Abstract excerpt
Plasmacytoid bladder cancer is an aggressive histologic variant with a high risk of disease-specific mortality. Using whole-exome and targeted sequencing, we find that truncating somatic alterations in the CDH1 gene occur in 84% of plasmacytoid carcinomas and are specific to this histologic variant. Consistent with the aggressive clinical behavior of plasmacytoid carcinomas, which frequently recur locally,...
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