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Article

Breast cancer prevention in patients with gBRCA-mutated ovarian cancer.

Journal of cancer research and clinical oncology - 21 Jun 2026

Amann Niklas, Krückel Annika, Brückner Lena, Gocke Julia, Müller Carolin, Heindl Felix, Hack Carolin C, Stumpf Katharina, Emons Julius, Fasching Peter A, Beckmann Matthias W, Hörner Manuel

Abstract excerpt

PURPOSE: Ovarian cancer is frequently associated with gBRCA1/2 mutations, which also confer a high lifetime risk of breast cancer in non-affected patients. While risk-reducing salpingo-oophorectomy (RRSO) is established in hereditary breast and ovarian cancer prevention, the recommendation for risk-reducing bilateral mastectomy (RRBM) remains unclear in gBRCA1/2mutovarian cancer patients due to high recurrence...

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Identifiers

PMID: 42323771
DOI: 10.1007/s00432-026-06543-4
PMCID: PMC13287192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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