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Article

Genetic modifiers of the Portfolio Diet Score and LDL cholesterol in young adults.

Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Oct 2026

Chen Victoria, Chiavaroli Laura, Glenn Andrea J, Kavanagh Meaghan E, Zeitoun Tara, Kendall Cyril Wc, Jenkins David Ja, Mahdavi Sara, El-Sohemy Ahmed, Sievenpiper John L

Abstract excerpt

BACKGROUND AND AIM: The Portfolio Diet has demonstrated clinically meaningful reductions in LDL-C concentrations. Variations in ABCA1, ABCG8, APOA5, ANGPTL3, and APOC1 have also been associated with LDL-C and other blood lipid concentrations. The interaction between these genetic variations and the Portfolio Diet on LDL-C is unclear. Therefore, we examined whether variations in genes involved in lipid metabolism...

Read the complete abstract on PubMed

Topics

Humans
Cross-Sectional Studies
Female
Cholesterol, LDL
Young Adult
Biomarkers

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Polymorphism, Single Nucleotide

Diet, Healthy

ATP Binding Cassette Transporter, Subfamily G, Member 8

Phenotype

ATP Binding Cassette Transporter 1

Adult

Angiopoietin-Like Protein 3

Ontario

Dyslipidemias

Diet, Plant-Based

Phytosterols

Source

Identifiers

PMID: 42323221
DOI: 10.1016/j.numecd.2026.104797

Genes

ABCG8
ABCA1
ANGPTL3
APOA5
APOC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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