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Article

Candidate-gene-based study of CYP3A-related single-nucleotide polymorphisms using 4β-hydroxycholesterol/cholesterol ratio as biomarker in a Japanese cohort.

European journal of clinical pharmacology - 19 Jun 2026

Tanaka Ryota, Suzuki Yosuke, Koyama Teruhide, Sumimoto Takahiro, Oda Ayako, Sato Haruki, Ozaki Etsuko, Tatsuta Ryosuke, Yamamoto Yasuyuki, Nakatochi Masahiro, Momozawa Yukihide, Ohno Keiko, Takashima Naoyuki, Matsuo Keitaro, Itoh Hiroki

Abstract excerpt

PURPOSE: CYP3A4 and CYP3A5 are major drug‑metabolizing enzymes that require electrons supplied by P450 oxidoreductase (POR) for catalytic cycle. CYP3A expression is regulated by the nuclear receptors; constitutive androstane receptor (CAR) and pregnane X receptor (PXR). Single-nucleotide polymorphisms (SNPs) of CYP3A5, CYP3A4, POR, CAR, and PXR have been documented to modulate CYP3A enzyme activity and/or...

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Source

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Identifiers

PMID: 42319470
DOI: 10.1007/s00228-026-04114-7
PMCID: PMC13282291

Genes

CYP3A5
POR
CYP3A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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